Enzyme Flexibility in Drosophila melanogaster

Abstract

POLYMORPHISMS for genetically determined enzyme variants have been reported in humans1, Drosophila2 and several other groups of organisms, but there is no adequate explanation for their occurrence. Genetic polymorphisms can be maintained in numerous ways3, but Haldane4 and Mayr5 have emphasized that geographical or temporal changes in the environment could place a premium on metabolic flexibility and that selection for heterozygotes or alternating selection for different homozygotes might establish the necessary enzyme heterogeneity in the population.

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