Phosphotyrosine Signaling: Evolving a New Cellular Communication System

Abstract

Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.

Topics

10 Figures and Tables

Download Full PDF Version (Non-Commercial Use)